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The ideal pre-treatment

DermWave™ Pro is also specifically designed to increase the permeability of the skin barrier. Active ingredients, creams and serums penetrate the skin better, as if by magic.
Newly designed handpieces for face and body with special circular loop technology, also used in Elon Musk’s TESLA, ensure 100% area effect without side effects.
Scientifically based treatment protocols and the preset DermWave™ Pro interface with all treatment parameters give the practitioner maximum safety.
The skin – the unknown being…
At approximately two square metres, the skin is the largest organ in the human body.
The outer layer of skin, the epidermis, is a dynamic system of continuous proliferation and differentiation.
The most important function of the skin, apart from its many other functions (temperature regulation, sensory organ,
protection against pollutants and mechanical influences) is the hydration barrier, which prevents the skin and the organism from drying out, and
maintaining the osmotic balance of internal tissues.
These functions are performed by the stratum corneum, the outermost layers of the epidermis.
In contact with the environment, horny cells are permanently worn away and corresponding keratinised keratinocytes are reproduced in the stratum basale.
This regenerative process normally takes about 20 days and is prolonged in the course of life,
whereby the water-binding capacity of the horny layer in particular decreases.
The skin loses elasticity, becomes dry and cracked and barrier damage occurs.
This makes the skin permeable to the penetration of microorganisms, pollutants, toxins and allergens.
Epidermal lipids are formed in insufficient quantity and composition.
The consequences are increased permeability of the horny layer and loss of hygroscopic substances and water.
Water is of crucial importance for the function of the skin.
Water is a transport medium and necessary for all physiological functions in the different skin layers.
The enzymes that are effective there can only fulfil their functions if there is sufficient hydration.
The correct pH value is a prerequisite for sufficient enzyme activities.
Water transport through cell membranes is a fundamental process of life.
Aquaporins are integral membrane proteins
Aquaporins
All living organisms regulate the inflow and outflow of water to the cells so that the function, shape and size of the cells are maintained.
Special proteins called “aquaporins” are responsible for this.
Aquaporins (AQP) are water channels that can be regulated externally to control the flow of water into and out of the cell.
All known aquaporins have a similar structure and amino acid sequence.
AQP1 consists of a chain of 268 amino acids. This forms six helices that span the membrane (integral membrane protein).
At the end of the helix is a characteristic structure consisting of three amino acids (aspara-gin-proline-alanine),
which contributes significantly to the selectivity of the water channel. [Farage MA. Textbook of Aging Skin, Springer-Verlag Berlin Heidelberg 2010].
Aquaporins have also been detected in the lipid membrane of the skin.
The lipid layer of the stratum corneum is water-repellent (hydrophobic) in its interior.
Therefore, its conductivity for water molecules is very low.

Fig 1: Aquaporins as integral structural proteins in the lipid membrane. [de Groot, B et al: Water Permeation Across Biological Membranes: Mechanism and Dynamics of Aquaporin-1 and GlpF, Science (2001), 294, 2353-2357]
For water to reach deep skin layers via the lipid layer,
free water must either be conducted through specific channels
or bound to hydrophilic substances along the desmo-some bridges into the epidermis.
The water content of the epidermis is regulated by the substances of the natural moisturising factor (NMF).
Barrier damage leads to increased water loss (TEWL = transepidermal water loss) and dry and sensitive skin.
LANDSBERG EDELWEISS® series and skinbetter science® products repair barrier damage and improve skin moisture and elasticity.
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